Lionel Messi will miss the next three weeks after suffering the recurrence of a groin injury as Atletico Madrid came from behind to hold Barcelona 1-1 at the Camp Nou on Wednesday.
Ivan Rakitic headed Barca into the lead just before halftime, but Angel Correa slotted home on the hour mark just seconds after Messi limped off to hand Atletico a deserved point.
Earlier, Real Madrid’s record-equalling 16-game La Liga win streak came to an end as Villarreal drew 1-1 draw at the Santiago Bernabeu.
Madrid continue to lead Barca by three points at the top of the table with Atletico a further point back in fourth.
Sevilla, who beat Real Betis on Tuesday, remain in second place.
“To lose Lionel Messi means football loses and we lose,” said Barca boss Luis Enrique.
“Now we have to look for other solutions. With Leo we are much stronger, but without him we are still a strong team.”
Messi is set to miss Barca’s next three games at Sporting Gijon and Celta Vigo in La Liga and Borussia Moenchengladbach in the Champions League, as well as Argentina’s World Cup qualifiers against Peru and Paraguay.
The five-time World Player of the Year missed Argentina’s last qualifier in Venezuela earlier this month due to a similar injury.
Barca’s stellar front three of Messi, Luis Suarez and Neymar had struck 10 times in their last two games, but were kept largely quiet by Atletico’s typically rock-solid defence.
Messi had the first effort on goal, but his fierce effort was comfortably handled by Jan Oblak in the Atletico goal.
The hosts had to wait until four minutes before the break to seriously threaten again when they took the lead.
Atletico momentarily switched off as a corner from the left was played short to Andres Iniesta and his cross was powered home by the late arriving Rakitic.
However, Barca’s joy was short-lived, first by a double injury blow and then Correa’s leveller.
Credit: Super Sports